Buddhist practice can be described as the relinquishing of grasping of self through an opening to what is other. This openness is found in many Buddhist practices and traditions, from attention to the singularity of each breath, to the abandonment of strongly held views, to the welcoming hospitality to other sentient beings. We see this in early Pāli texts on mindfulness, in the Madhyamaka critiques of metaphysical claims, in the ethical practices of the bodhisattva, in meditations on exchanging self and other, and in the Pure Land practice of letting the ego fall away and thereby making space for an 'other power.' As Sāntideva points out, learning to appreciate the other's perspective–attending to the needs, suffering, and desires of others–is at the heart of cultivating wisdom and compassion. Drawing on theories and practices from a variety of Buddhist traditions, we will explore opening to what is other as a spiritual practice. We will also address some of the ways we are called today to cultivate openness to difference when we recognize the intertwining of spiritual practice, ethics, and justice.