The last decade has seen a rapid rise in the engagement of scientific research with Buddhist thought and practice. This program will focus on the question of transformation with an emphasis on meditation and the brain. Through lectures and discussion, we will explore recent research findings, as well as a theoretical convergence between Buddhist ideas of karma and delusion on one hand, and neuro-scientific models of brain plasticity and concept formation on the other. This program is for non-scientists and scientists alike, and will also include elements of formal meditation practice.